解剖学与组织胚胎学系介绍

复旦大学大学基础医学院解剖与组织胚胎学系成立于2002年,由原人体解剖学教研室和组织胚胎学教研室合并而成,均源于1927年建校之初的解剖学科。学科奠基人为张鋆、王有琪、齐登科和郑思竞教授等国内外著名的解剖学家。

本学科为国内最早的硕士、博士学位授予点和博士后流动站,先后两次(1989和2001年)被评为国家重点学科,属于国家“211工程”和“985工程”重点建设学科。主要承担人体解剖学和组织胚胎学的教学、科研、研究生培养和高级师资培训等工作。

历年来,本学科聚集了一大批知名专家教授,如蒋文华、谷华运、胡哲葵、成令忠、陈芝仪、童夙明、陈丽琏、于彦铮、钱佩德、王惠仁、周孝瑚、沈宗文、沈馨亚、刘才栋、罗宝国、左焕琛、彭裕文、钟翠平和王克强等,促进了学科深入持久的发展,取得了辉煌成就。近年来,在中青年学科带头人彭裕文、周国民和宋志坚等教授的带领下,发扬优良传统,不断开拓创新,正在再创新的辉煌。

本系现有教职员工40余人,在读研究生20多人,其中教授7人,副教授5人,副主任技师1人。现任系主任为周国民教授,支部书记为李文生副教授。



           Introduction to the Dept. of Human Anatomy &Histoembryology

I. Scientific Overview

1. Background

The discipline of Human Anatomy and Histoembryology has been mainly composed of 3 units through the academic development of nearly ten decades: the Department of Human Anatomy, Histology & Embryology set up in 1927, the Digital Medicine Research Center in 2000, and the Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai in 2006.

The discipline can be traced back to 1927, when the Department of Human Anatomy was principally set up by Prof. ZHANG Yun, WANG Youqi, and QI Dengke. Afterwards, Prof. Remen and TAN Youli, well-known experts in the world, began to work in the Department. Thanks to the successive efforts, the discipline has evolved to make many achievements. It was authorized to confer PhD degrees for the first time in 1981; recognized as the National Key Subject in 1989 and 2001, respectively; authorized as the Development Subject of “211 High Education Projectt” in 1998 and 2001, respectively; approved thrice as the National Key Construction Program of “985” Project since 2001; and had Graduate Innovation Laboratory of The Digital Medicine Research Center authorized as National Innovation Project of Graduate Education in 2007.

1.1.The Staff

The discipline of Human Anatomy, Histology & Embryology has a staff of 42, among whom 31 are researchers and instructors and 11, technicians. Of the faculty, there are 8 full professors, 9 associate professors and 14 lecturers, those who hold PhD degrees accounting for 90.3% and those who pursued studies abroad, 74.2%.

Concurrently, SONG Zhijian is titled as Shanghai Outstanding Medical Academic Leader, and also as Shanghai Subject Chief Scientist; ZHOU Guomin and SONG Zhijian, as “ShuGuang” Scholars by Shanghai Municipal Education Commission and Shanghai Education Development Foundation; LI Wensheng, as Shanghai Outstanding technical leader; and LIANG Chunmin, as talented scientist in Shanghai Pujiang Program.

1.2.Medical Education

The Curriculum

The discipline of Human Anatomy and Histoembryology offers such medical courses to BM undergraduates as Gross Anatomy (exclusively in English), Regional Anatomy (exclusively in English), Histology & Embryology (exclusively in English), Normal Morphology and Function of the Human body, and the Mysteries of the Human Body.

To PhD and MD medical graduates are offered Developmental Neurobiology, Advanced Regional Anatomy, Sectional Anatomy, Neuroanatomy, Clinical Vascular Anatomy, Advanced Clinical Applied Anatomy, Progress in Histology, Progress in Embryology, Reproductive Medicine & Reproductive Biology, Cytoskeleton and Cell Movement, Plastic Surgery Anatomy, Introduction of Medical Informatics, Progress in Biomedical Engineering, Java Program Design, Neural Culture, Practical Cell Culture Technology, Practical Immuno-electron Microscopy, Advanced Medical Photography Theory and Technology.

Awards

In curriculum construction, awards have been won for the nationally planned textbook compiling and teaching skills since 2009. For example, the course of Regional Anatomy won the National Quality Resources Sharing Class in 2013, the National Elite Course in 2007, and the Shanghai Elite Course in 2005. Similarly, the course of Histology & Embryology won the Shanghai Elite Course in 2004, and the course of Histology & Embryology in English won the 2nd Prize of Shanghai Teaching Achievements Award in 2013 and the Shanghai Model Course in English in 2014. The course of The Mysteries of the Human Body won the Key Construction Course of Shanghai Education Committee in 2011. The Human Gross Anatomy of the 11th five-year-plan Textbook complied by Prof. WANG Haijie as the editor-in-chief was awarded the 2nd Prize of the Excellent Textbook of the National University and the 3rd Prize of the Excellent Textbook of Shanghai Higher College. ZHANG Lihong won the 2nd Prize of Youth Teacher Basic Teaching Skills Competition of the National Higher Medical College in 2012.

The Nationally Planned Textbooks Compiled

Prof. PENG Yuwen as the editor-in-chief and Prof. LI Ruixi as the associate editor-in-chief compiled the 7th edition of Regional Anatomy (the 11th five-year-plan Textbook) published by People’s Medical Publishing House for undergraduates by the Ministry of Health. Prof. LI Ruixi is also the editor-in-chief of the 8th edition of Regional Anatomy (the 12th five-year-plan Textbook) published by People’s Medical Publishing House for undergraduates by the Ministry of Health, and is the associate editor-in-chief of Regional Anatomy published by Sciences Press as one of the 12th five-year-plan Textbooks for higher medical education and as the bilingual textbook for national higher medical college.

As the editor-in-chief, Prof. WANG Haijie compiled Human Gross Anatomy as the 11th five-year-plan Textbook, Gross Anatomy as the 12th five-year-plan Textbook by Health and Family Planning Commission, and Clinical Applied Anatomy as the National University Graduates Textbook, and also as the associate editor-in-chief compiled Human Morphology and Systemic Anatomy in English as tthe 12th five-year-plan Textbook, Anesthesia Anatomy as the Medical Planning Textbook. Prof. ZHOU Guomin as the associate editor-in-chief compiled Histoembryology the 11th five-year-plan Textbook for Medical Undergraduate by Ministry of Health and Histoembryology of the 11th five-year-plan Textbook by the General Higher Education.

Graduate Studies

Since 2009, the discipline has enrolled 57 graduates, 37 as PhD candidates. Currently, there are 25 PhD candidates and 9 MS candidates. Since 2009, the discipline has conferred 24 PhD degrees and 25 MS degrees, some of them showing great potential in scientific research with publications in the top journals of Antioxid Redox Signal.(ARS), and getting the grants from National Natural Science Foundation of China (NSFC).

1.3. Research Summary

The scientific research focuses on 3 areas: the basic research of reproduction and neural development; clinical applied anatomy and digital medicine; and regenerative cardiovascular medicine.

Since 2009, 68 scientific grants, municipal and national, have been approved in the total amount of nearly RMB20, 000,000.00. They are respectively supported by National High-tech R&D Program of China (“863” Program), National Key Technology Research and Development Program of the Ministry of Science and Technology of China, National Program on Key Basic Research Project of China (“973” Program Subproject), and National Natural Science Foundation of China (NSFC). Thereby, 81 papers have been published in the international peer-reviewed journals, 28 of which were documented in those of impact factor beyond 3.0, also including the top journals of CELL stem cell, Antioxid Redox Signal (ARS), Journal of Neurosciences (JN). The research achievements, moreover, have won 3 Awards of Scientific and Technological Progress, municipally and nationally, one of them, the 2nd Prize of National Technological Invention in 2012, and also 7 national patents authorized.

Joint efforts have been made in the construction of Morphology Research Platform, School of Basic Medical Sciences of Fudan University. Now the laboratory is equipped with a confocal laser scanning microscope, stereo fluorescence microscope, and freezing microtome in the total area of 1,500.00 m2. It functions as follows: tissue section and staining, image capture and analysis, cell culture, clinical anatomy. Recently, Human Museum has joined the platform.

2.The Major Research Projects and Their Teams

2.1.Basic research of Reproduction and Neural Development

2.1.1. Research Summary

The basic research of reproduction and neural development is an integration of its traditional edge of the research on developmental biology and reproductive biology, and the advanced technology of the research on stem cell. It is closely combined with the clinical research on the reproduction and development, with an emphasis on its translational medicine. The research focuses on: 1) the whole-scale study of the differentiation of stem cell to various neural cells; 2) the neural pathway mechanisms on the sleep; 3) the mechanisms of the neural pathological changes on autism, depression, and Alzheimer’s disease; 4) spermatocyte differentiation and its epigenetic mechanism; and 5) liver immunology.

2.1.2. The Principal Investigator

ZHOU Guomin (1962-), professor, PhD of former Shanghai Medical University, Postdoctor of University of Tennessee of USA, Shanghai “Shu Guang“ Scholar, currently serves as director of the department, chair of Shanghai Society for Anatomy Sciences, Deputy Chair of China Society for Anatomy Sciences.

Zhou’s research focuses on the development and regeneration of visual function (mainly in retina), and the major research accomplishments are the mechanism of retinal Műller cells regenerating visual cells; and setting up the animal model of myopia in premature birth and its mechanism study. Since 2009, ZHOU Guomin has won 19 grants in the total amount of RMB3,000,000.00, in which 2 were supported by USA NIH Subproject, 1 by 973 Program Subproject, 6 by NSFC, and 10 by the other municipal projects. And he has published 12 papers in the international peer-reviewed journals such as Brain Research Bullentin, FEBS Journal, and Biometals.

2.1.3The Core Team Members

PENG Yuwen (1945- ), professor, PhD of former Shanghai Medical University, visiting scholar and professor of Osaka University of Japan, and senior visiting acholar of Stanford University of USA

Peng’s research focuses on the application of anatomy and basic theory of the ache from spine, neck, shoulder, waist, and leg. The major research achievements are as follows: PENG Yuwen has won 4 grants from NSFC, and published 10 papers in the international peer-reviewed journals.

LI Ruixi (1955- ), professor, PhD of Toyama University of Japan

Li’s research focuses on the association of neural pathway with its function in brain, and the major research accomplishment is as the follows: 1) suggesting the neural morphological evidence of emotional learning and memory associated with the nerve endings interaction of cholinergic and noradrenergic in amygdale; 2) proving the possible neural pathway of sleep-wake regulation by A2A receptor neurons in nucleus accumbens. Since 2009, LI Ruixi has got 2 grants supported by NSFC in the total amount of RMB1, 000,000.00, and published 15 papers in the international peer-reviewed journals such as Front Neuroanat and CNS Neurol Disord Drug Targets.

CHEN Hong (1967- ), professor, PhD of the University of Hong Kong, Postdoctor of University of Delaware of USA

Chen’s research focuses onspermatocyte differentiation and its epigenetic mechanisms, and the major research accomplishments are as follows: the discovery of the mechanism of DNA damage and repair in sperm; and the finding of the function of mitochondrial PHB on regulation of human sperm motility. Since 2009, CHEN has got 4 grants in the total amount of RMB2, 230,000.00, 3 supported by NSFC and 1 by 973 Program Subproject. And she has published 4 papers as the first/correspondence author in the international peer-reviewed journals such as Free Radical Biology & Medicine and Antioxid Redox Signal. CHEN Hong also got one of the USA patent with the No. 7531299.

LIANG Chunmin (1972- ), associate Professor, PhD of Fudan University, Postdoctor of Innsbruck Medical University of Austria, title holder of Shanghai Pujiang Program

Liang’s research focuses on liver immunology, and the major research accomplishments are as follows: the possible association of chemokine and its receptor in liver tumor microenvironment with tumorigenesis and metastasis, and the application of immune-biological therapy. Since 2009, LIANG Chunmin has got 6 grants from NSFC and 973 Program Subproject in the total amount of RMB1,800,000.00, and published 8 papers in the international peer-reviewed journals.

LIU Qiong (1978- ), associate Professor, PhD of Fudan University, Postdoctor of University of Harvard of USA

Liu’s research focuses on the neural development and the effects of glial cell on depression, and the molecular mechanism of Necroptosis on neuron, and the major research accomplishments are as follows: 1) clarifying that the occurrence of depression is associated with neural development and related glial cell in hippocampus; 2) finding the regulation of Akt/mTOR signal pathway on Necroptosis. Since 2009, LIU Qiong has got 2 grants supported by NSFC in the total amount of RMB1, 100,000.00, and published 6 papers in the international peer-reviewed journals such as Cell Death &Dis. and J Affect Disord.

MA Lixiang (1971- ), associate professor, MS of Fudan University, visiting scholar of University of Wisconsin of USA

Ma’s research focuses on the differentiation targeting neural cell of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs) as well as its effect on neurodegenerative diseases, and the major research accomplishments are as follows: 1) finding a method to get more GABA neurons from hESCs; 2) showing evidence that GABA neurons-transplanted can set up new neural circuitsand produce right neurotransmitters. Since 2009, MA Lixiang has got 2 grants from NSFC in the total amount of RMB800,000.00, and published 5 papers in the international peer-reviewed journals such as Cell Stem Cell, Nature Biotechnology, PNAS and Development.

ZHANG Lihong (1973- ), associate Professor, PhD of China Medical University, visiting scholar of University of New South Wales.

Zhang’s research focuses on the association of Trace element zinc/iron and its related protein with nervous system-related diseases, and the major research accomplishments are as follows: 1) Abnormal expression of zinc and its transporters in Alzheimer’s disease; 2) the effect of histone modification on proliferation of neuroblastoma. Since 2009, ZHANG Lihong has got 2 grants from NSFC in the total amount of RMB270,000.00, and published 2 papers in the international peer-reviewed journals of Neurobiology of Aging and Oncology Report.

2.1.4The Representative Publications

1.Liu LY, Wu J, Zhou X, Chen Z, Zhou GM*. The impact of visible light on the immature retina: a model of early light exposure in neonatal mice. Brain Res Bull. 2012;87(6):534-9.

2.   Li Y, Zheng H, Liu PP, Chen YY, She ZJ, Xiao HL, Zhou GM*. The new targets of ouabain in retinal interneurons of Sprague-Dawley rats. Brain Res Bull. 2010;81(6):617-24.

3.   Ma L, Hu BY, Liu Y, Vermilyea SC, Liu H, Gao L, Sun Y, Zhang X , Zhang SC*. Human Embryonic Stem Cell-Derived GABA Neurons Correct Locomotion Deficits in Quinolinic Acid-Lesioned Mice. Cell Stem Cell.2012;10(4), 455–64.

4.   Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, de Kerchove d'Exaerde A, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX*. Projections of nucleus accumbens adenosine A2A receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation. Front Neuroanat.2013; 7: 43.

5.   Zhang Y, Yuan X, Wang Z, Li R*. The canonical wnt signaling pathway in autism. CNS Neurol Disord Drug Targets. 2014;22. [Epub ahead of print]

6.   Cui W, Tao J, Wang Z, Ren M, Zhang Y, Sun Y, Peng Y, Li R*. Neuregulin1beta1 antagonizes apoptosis via ErbB4-dependent activation of PI3-kinase/Akt in APP/PS1 transgenic mice. Neurochem Res. 2013;38(11):2237-46.

7.   Cui W, Sun Y, Wang Z, Xu C, Peng Y, Li R*. Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1transgenic mice. Neuroscience. 2012;17; 210: 200-10.

8.   Chen H*, Cheung MPL, Chow PH, Cheung ALM and O WS*. The Effects of Sperm DNA Damage on the Levels of RAD51 and p53 Proteins in Zygotes and 2-cell Embryos Sired by Golden Hamsters without the Major Accessory Sex Glands. Free Radical Biology & Medicine. 2012;53: 885-92.

9.   Wang MJ, Ou JX, Chen GW, Wu JP, Shi HJ, O WS, Martin-DeLeon PA. Chen H*. Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility and male fertility? Antioxid Redox Signal. 2012;17(3):513-59.

10.  Shi TY, Chen G, Huang X, Yuan Y, Wu X, Wu B, Li Z, Shun F, Chen H* & Shi HJ*. Effects of reactive oxygen species from activated leucocytes on human sperm motility, viability and morphology. Andrologia. 2012;44: 696-703.

11.  Chen H, Zhao HX, Huang XF, Chen GW, Yang Z, Sun W, Tao MH, Yuan Y, Wu J, Sun F, Dai Q, Shi HJ*. Does high load of oxidants in human semen contribute to male factor infertility? Antioxid Redox Signal. 2012;16(8):754-759.

12.  Chen L, Ma H, Hu H, Gao L, Wang X, Ma J, Gao Q, Liu B, Zhou G, Liang C*.. Special role of Foxp3 for the specifically altered microRNAs in T regulatory cells of HCC patients. BMC Cancer. 2014;14:489

13.  Ma H, Wei Y, Leng Y, Li S, Gao L, Hu H, Chen L, Wang F, Xiao H, Zhu C, Liang C*. TGF-β1-induced expression of Id-1 is associated with tumor progression in gastric cancer. Medical Oncology.2014; 31(7):19. doi: 10.1007/s12032-014-0019-3.

14.  Chen L, Zhou S, Qin J, Hu H, Ma H, Liu B, Wang X, Ma J, Ye S, Zhong C, Zhou G, Liang C*. Combination of SLC Administration and Tregs Depletion Results in the Maximal Tumor Regression. Molecular Cancer.2013; 12(1):153-164.

15.  Zhou S, Shen Z, Wang Y, Ma H, Zhong C, Yang Y, Liang C*.CCR7 Expression and Intratumoral FOXP3+ Regulatory T Cells are Correlated with Overall Survival and Lymph Node Metastasis in Gastric Cancer. PLoS ONE. 2013;8(9): e74430. doi:10.1371/journal.pone. 0074430.

16.  Li R, Hu H, Ma H, Chen L, Zhou S, Liu Y, Liang C*. Tregs infiltration effect antitumor. Molecular Biology Report.2013; 40(10):5615-23.

17.  Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ*. .Akt and mTOR mediate programmed necrosis in neurons. Cell Death Dis. 2014;27;5:e1084. doi: 10.1038/cddis.2014.69.

18.  Liu Q, Zhu HY, Li B, Wang YQ, Yu J*, Wu GC*. Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression. J Affect Disord. 2012;10;141(2-3):367-372.


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