Ⅰ. Choose the best answer (only one choice is correct or appropriate)
(2 point for each):
1. During the 20th century, the developed counties experienced a change in leading causes of death
(a) from primarily infectious diseases to primarily chronic diseases.
(b) from primarily chronic diseases to infectious diseases
(c) due to increases in infant mortality and decreases in diseases of the elderly.
(d) due to decreases in infant mortality and decreases in diseases of the elderly.
2. Benign tumors always .
(a) are poorly differentiated
(b) have prominent mitotic figures
(C) frequently develop metastasis
(d) do not invade or infiltrate the surrounding normal tissues
3. Current surgical pathology is concerned with the .
(a) diagnosis and classification.
(b) anatomic and biochemical features.
(c) disease progression and prognosis.
(d) all the above.
4. Which one is the tumor marker?
(a) AFP (b) platelet
(c) red blood cell (d) ALT
5. Which tumor marker has been widely used for prostate carcinoma?
(a) CEA (b) CA 19-9
(c) PSA (d) CA 125
6. Tumor markers .
(a) can not predict response or toxicity from treatment.
(b) are carcinogens
(c) can induce malignancies
(d) can be used for the early detection of tumor, diagnosis of cancer, and monitoring of cancer response to therapy, such as CA125, CEA and PSA
7. Karnofsky performance status (KPS) is used for evaluation of
(a) liver function. (b) kidney function
(c) cardio-vascular disease. (d) patient general condition.
8. For cancer staging which stage systems are widely used in the world?
(a) UICC (b) AJCC
(C) Child-Pugh. (c) UICC and AJCC
9. In cancer therapy multidisciplinary approach treatment means:
(a) using multiple treatment modalities
(b) surgery combined with irradiation
(c) Chinese herbs with chemotherapy
(d) palliative therapy with others
10.The roles of surgery in oncology include:
(b) radical dissection
(d) all the above
11. The treatment of choice for early stage of breast cancer is:
(a) radical surgery
(b) radiotherapy alone
(c) conservative surgery combined with chemotherapy and radiotherapy
(d) chemotherapy and radiotherapy
12.How many years are the history of radiotherapy for cancers?
(a) 50 years (b) over 100 years
(c) 20 years (d) 80 years
13.Which cancer shown below is treated primarily by radiotherapy?
(a) breast cancer (b) nasopharyngeal cancer
(c) melanoma (d) rectal cancer
14.Radiotherapy delivered to the primary lesion following breast conservative surgery in breast cancer patient NOT with the purpose of:
(a) better local control (b) better wound healing
(c) reduction of distant metastases (d) survival improvement
15.Which is strong narcotic analgesics drug?
(a) codeine (b) tramadol (c) steroids (d) morphine
16.Which are the significance of palliative care?
(a) make patient comfort physically and psychologically
(b) respect the life
(c) help the patients’ family with grief and bereavement support
(d) all the above
17.The treatment of choice for colon cancers is:
(a) chemotherapy alone (b) radiotherapy
(c) surgery combined with chemotherapy (d) immunotherapy
18.Which malignancy could be cured by chemotherapy alone?
(a) acute lymphocytic leukemia (b) liver cancer
(c) pancreatic cancer (d) breast cancer
19.According to the Common Terminology Criteria for AE (CTCAE V 4.0), how many grades there are?
(a) 2 (b) 3 (c) 4 (d) 5
20.Which one is NOT the principles of combination of multiple chemotherapy agents?
(a) synergistic mechanisms
(b) overcome of the chemo-resistance
(c) optimal dose and schedule
(d) less toxicity than single agent
II. Question and answer:
1. What is neoplasia and what are its three important features? (20 points)
2. Please briefly introduce the phase I, II and III studies for new drug development (20 points)
3. Please give a brief introduction about the strategies of cancer prevention (primary, secondary and tertiary prevention)? (10 points)
4. Please briefly state the definition of multidisciplinary treatment model for cancer patient care (10 points).