Course Director Prof. Hong CHEN
作者:     更新日期: 2014-04-02     访问次数: 486

 

Course Director Prof. Hong CHEN

Hong CHEN (陈 红)

Professor

B.Med., M.Med. (Shanghai Med. Univ.), Ph.D.(HKU), Reprod.Biol.

 

Department of Anatomy, Histology & Embryology

138 Yixueyuan Road

Shanghai, 200032

China

 

Phone: + 86 (21) 54237019, Ext. 9304

Fax: + 86 (21) 54237027

Office: Room 304, 9 Building (east)

E-mail: hchen30@hotmail.com; hchen@graduate.hku.hk

 

Background

 

Education/Training

 

·           B. Med., Shanghai Medical University, China (1984-1990)

·           M. Med., Shanghai Medical University, China (1992-1997)

·           Mrs. Ivy Fellow, The University of Hong Kong, China (1999-2000)

·           Ph.D. The University of Hong Kong, China (2000-2004)

·           Postdoctoral Fellow, University of Delaware, USA (2003-2004)

 

 

Other Affiliations

 

·           Member, Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai

·           Member, Society for the Study of Reproduction (SSR, USA)

·           Member, Society for Reproduction and Fertility (SRF,UK)

·           Member of Chinese Society for Anatomical Sciences

·           Member of Shanghai Society for Anatomy Sciences

·           Member of Shanghai Medical Association

 

  

Teaching

 

Courses

 

·           Histology & Embryology

·           Histology & Embryology (English)

·           Reproductive Medicine & Reproductive Biology

·           Histology Progress

·           Embryology Progress

Teaching Grants

·           Fudan Univ. Education Research Project (No.2013YB30), MOOCs Course Construction of Histology & Embryology (English) (2014-2015)

·           Shanghai Med. College Education Research Project (No. 201010), Construction of Formative Grading Criteria in Teaching of Histology & Embryology (2010-2012)

·           Fudan Univ. Education Research Project, Course Construction of Histology & Embryology (English) (2008-2010)

Editorships

·           Chief Editor, Practical Manual of Histology (1st English Edition) (2012)

·           Chief Editor, Practical Manual of Histology (1st Chinese Edition) (2012)

·           Member of editorial board, The Human Body (2008, 2014)

·           Member of editorial board, Modern Histology (2004)

Teaching Awards and Honors

  • The 2nd Award of Shanghai Teaching Achievement in Course Construction of Histology & Embryology (English) as Course Leader (2013)
  • The 3rd Award in Young Teachers Teaching Contest of Fudan University (2011)
  • The 1st Award of Fudan University Teaching Achievement in Course Construction of Histology & Embryology (English) as Course Leader (2010)
  • The National Excellent Book Award (Sciences) for Book <The Human Body> as member of editorial board (2009)
  • · The National Excellent Book Award for Book <Modern Histology> as member of editorial board (2004)

 

 

Research

 

 

Research Interests

 

·           Epigenetics of male infertility

·           Sperm mitochondria disorders

·           Sperm DNA damage and repair

 

Research Description

 

A leading cause of increased male infertility worldwide is degeneration of sperm quality mainly in the aspects of sperm amounts and functions. ROS, such as superoxide anions, hydroxyl radicals, and hydrogen peroxide, are free radicals and have been shown to influence the structural integrity of spermatozoa and their functions, including motility, capacitation, and sperm–oocyte fusion. Once the fine balance needed to maintain the optimal level of ROS controlled by antioxidant factors in secretions of the male reproductive system is lost, then the sperm may experience oxidative stress with resulting sperm dysfunction, even oxidative DNA damage and apoptosis, which eventually leads to male infertility. To date, patients with sperm quality degeneration, such as amounts and functions, have more possibilities for therapy.

 

Research Grants

 

·           National Basic Research Program of China (973 program) (China) (2014-2018).

·           NSFC (China) (2009; 2011-2013; 2013-2016)

Research Awards and Honors

·           The 3rd Award in the 2nd Contest of National Undergraduates in Basic Sciences Innovation Forum & Experimental Design as supervisor (2012)

·           TREBR Award (Trust for Research and Education in the Biology of Reproduction, TREBR), SRF, UK (2003)

·           Conference Grant Award, Center of Human Reproduction, The University of Hong Kong (2003)

·           Conference Grant Award, Hong Kong Society of Endocrinology, Metabolism and Reproduction (HKSEMR), Hong Kong (2002)

·           Full PhD studentship, The University of Hong Kong (2000-2003)

·           Mrs. Ivy Wu Fellowship, The University of Hong Kong (1999-2000)

·           LU CHAO Preventive Medicine Foundation Award (1999)

·           The 2nd Award of Shanghai Science and Technology Progress Award (as animal experiment completer) (1995)

Patents

·           US Patent “In vitro uptake of SPAM1 (PH-20) by Mammalian Sperm”.  Patent No. 7531299. (2009)

 

Paper Highlight

1.    Chen H*, Cheung MPL, Chow PH, Cheung ALM and O WS. (2012) The Effects of Sperm DNA Damage on the Levels of RAD51 and p53 Proteins in Zygotes and 2-cell Embryos Sired by Golden Hamsters without the Major Accessory Sex Glands. Free Radical Biology & Medicine. 53: 885-892.

2.    Wang MJ, Ou JX, Chen GW, Wu JP, Shi HJ, O WS, Martin-DeLeon PA. Chen H. (2012) Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility and male fertility? Antioxid Redox Signal. 17(3):513-519.

3.    Chen H, Griffiths G.S., Galileo D.S., Martin-DeLeon P.A. (2006) Epididymal SPAM1 is a marker for Sperm Maturation in the Mouse. Biol Reprod. 74 (5): 923-930.

4.    Chen H, Cheung MPL, Chow PH, Cheung ALM, Liu W and O WS. (2002) Protection of sperm DNA against oxidative stress in vivo by accessory sex gland secretions in male hamsters. Reproduction, 124: 491-499.

5.    Chen Hong and Tong Su-ming. (1998) Effects of Mifepristone (RU486) on Hypophysis, Ovary, Uterus and Placenta in Pregnant Rats. Biomedical and Environmental Sciences, 11(2):133-139.

 

 Selected Publications

  

1.    Chen H, Cheung MPL, Chow PH, Cheung ALM and O WS. (2012) The Effects of Sperm DNA Damage on the Levels of RAD51 and p53 Proteins in Zygotes and 2-cell Embryos Sired by Golden Hamsters without the Major Accessory Sex Glands. Free Radical Biology & Medicine. 53: 885-892.

2.    Wang MJ, Ou JX, Chen GW, Wu JP, Shi HJ, O WS, Martin-DeLeon PA. Chen H. (2012) Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility and male fertility? Antioxid Redox Signal. 17(3):513-519.

3.    Shi TY, Chen G, Huang X, Yuan Y, Wu X, Wu B, Li Z, Shun F, Chen H* & Shi HJ*. (2012) Effects of reactive oxygen species from activated leucocytes on human sperm motility, viability and morphology. Andrologia. 44: 696-703.

4.    Chen H, Zhao HX, Huang XF, Chen GW, Yang Z, Sun W, Tao MH, Yuan Y, Wu J, Sun F, Dai Q, Shi HJ. (2012) Does high load of oxidants in human semen contribute to male factor infertility? Antioxid Redox Signal. 16(8):754-759.

5.    Chen H, Griffiths G.S., Galileo D.S., Martin-DeLeon P.A. (2006) Epididymal SPAM1 is a marker for Sperm Maturation in the Mouse. Biol Reprod. 74 (5): 923-930.

6.    O WS, Chen H, Chow PH. (2006) Male genital tract antioxidant enzymes-Their ability to preserve sperm DNA integrity. Molecular Cell Endocrinology. 250: 80-83.

7.    Martin-DeLeon PA, Zhang H, Morales CR, Zhao Y, Rulon M, Barnoski BL, Chen H and Galileo DS. (2005) Spam1-associated transmission ratio distortion in mice: Elucidating the mechanism. Reproductive Biology and Endocrinology, 3:32.

8.    Chen H, Chow PH, Cheng SK, Cheung ALM, Cheng LYL and O WS. (2003) Male genital tract antioxidant enzymes: their source, function in the female and ability to preserve sperm DNA integrity in the golden hamster. Journal of Andrology, 24(5): 704-711.

9.    Chen H, Cheung MPL, Chow PH, Cheung ALM, Liu W and O WS. (2002) Protection of sperm DNA against oxidative stress in vivo by accessory sex gland secretions in male hamsters. Reproduction, 124: 491-499.

10.  Chen Hong and Tong Su-ming. (1998) Effects of Mifepristone (RU486) on Hypophysis, Ovary, Uterus and Placenta in Pregnant Rats. Biomedical and Environmental Sciences, 11(2):133-139.