Associate Prof. Qiong LIU
作者:     更新日期: 2014-04-01     访问次数: 149

 

Qiong LIU (刘琼)

Associate Professor

B.Sci.(Xinxiang Med. College), Ph.D.(Fudan Univ.), Neuroscience

 

Department of Anatomy, Histology & Embryology

138 Yixueyuan Road

Shanghai, 200032

China

 

Phone: + 86 (21) 54237019, Ext. 9208

Fax: + 86 (21) 54237027

Office: Room 208, 9 Building (east)

E-mail: liuqiong@fudan.edu.cn

 

 

Background

 

 

Education / Training

 

·           B.Sci. Xinxiang Medical College, Henan, China (1995-2000)

·           Ph.D. Fudan University Shanghai Medical College, China (2003-2008)

·           Postdoctoral Research Fellow, Massachusetts General Hospital, Harvard Medical  School, USA (2011-2013)

 

 

Other Affiliations

 

·           Member of Chinese Society for Anatomical Sciences

·           Member of Chinese Society for Neuroscience

·           Member of Shanghai Society for Anatomy Science

·           Member of Shanghai Medical Association

 

 

 

Teaching

 

Courses

 

·           Histology & Embryology

·           Histology & Embryology (English)

·           Developmental Neurobiology

·           Neural cells culture

·           Histological progress

Awards and Honors

·           The first Sankyo Pharmaceutical Scholarship for Young Faculty, Fudan University (2011 )

·           Hong Kong Teaching Awarding of Fudan University (2010 )

 

 

 

Research

 

Research Interests

 

·           Depressive disorder

·           Neuro-inflammation

 

Research Description

 

Depressive disorder is the heterogenic disease. Activation of inflammatory, oxidative, and nitrosative stress pathways plays an important role in the pathophysiology. Increased levels of proinflammatory mediators are now well established in depression. Our laboratory recently reported the involvement of astroglia in the rat chronic unpredictable stress (CUS) induced depression model. We also got the data in which it showed the activation of microglia and the increase of proinflammatory cytokine IL-1beta in the hippocampus of depression model rats . These observations suggest a primary role for inflammation in the pathogenesis of depression. Detection of the inflammation in the brain will lead to a greater understanding of depression mechanisms, and will identify potential therapeutic targets to limit inflammation in the brain and improve neurological function in our depression model and ultimately in patients with depressive disorder.

 

Research Grants

 

·           NSFC (2009-2011; 2014-2017)

Awards and Honors

·           IBRO School Award, International Brain Research Organization (IBRO)  (2010 )

·           National Excellent Doctoral Dissertations Nominee NO, 2010112), China  (2010 )

·           Excellent Doctoral Dissertations, Fudan University, Shanghai, China  (2010 )

·           Excellent Doctoral Dissertations, Shanghai Higher Education Committee  (2009)

 

 

 

Selected Publications

 

1.    Li B, Yang CJ, Yue N, Liu Y, Yu J, Wang YQ, Liu Q*, Wu GC*. Clomipramine Reverses Hypoalgesia/Hypoesthesia and Improved Depressive-Like Behaviors Induced by Inescapable Shock in Rats. Neurosci Lett. 2013 Apr 29;541:227-32.

2.    Liu Q, Zhu HY, Li B, Wang YQ, Yu J, Wu GC. Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression. J Affect Disord. 2012 Dec 10;141(2-3):367-372.

3.    Liu Q, Li B, Zhu HY, Wang YQ, Yu J, Wu GC. Glia atrophy in the hippocampus of chronic unpredictable stress-induced depression model rats is reversed by electroacupuncture treatment. J Affect Disord 2011 Feb;128(3):309-13. 

4.    Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X, Zou H, Qiu J. Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts. PLoS ONE 2011 6(11):e27081.

5.    Liu Q, Li B, Zhu HY, Wang YQ, Yu J, Wu GC. Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression. Eur Neuropsychopharmacol. 2009 Nov;19(11):796-805. 

6.    Liu Q, Yu J, Mao-Ying QL, Mi WL, Li B, Wang YQ, Wang J, Wu GC. Repeated clomipramine treatment reversed the inhibition of cell proliferation in adult hippocampus induced by chronic unpredictable stress. Pharmacogenomics J. 2008 Dec;8(6):375-83.

7.    Liu Q, Yu J, Mi WL, Mao-Ying QL, Yang R, Wang YQ, Wu GC. Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress. Life Sci. 2007 Nov 10;81(21-22):1489-95.