Background

Education/Training

·           B.Med., Wannan Med. College. China (1989-1994)

·           M.Med., Wannan Med. College. China (1997-2000)

·           Ph.D., Shanghai Med. College, Univ. of Fudan, Shanghai, China (2002-2005)

·           Postdoctoral Fellow, Innsbruck Medical Universityl, Austria (2007-2008)

Other Affiliations

·           Member, Liver Cancer Institute, ZhongshanHospital, University of Fudan

Teaching

Courses

·           Histology & Embryology

·           Histology & Embryology (English)

·           Liver Immunology

·           Neuro-immunology

Research

Research Interests

·           The microenvironment of tumors and central nerve system

·           Immunological therapy for cancers and Alzheimer’s diseases

Research Description

The tumor microenvironment is similar to that of central nerve system to some extend, for example, higher expression of TGF-β,higher infiltration of Tregs and some other negative regulation cytokines for immunological system. Immune senescence with aging has also played a crucial role in tumor and AD development. We focus on finding new treatments for tumors and neurodegenerative diseases by immunological therapy ways, by stimulating inactive immune effecter cells and reversing immune senescence.

Research Grants

·           No.2011CB910700. The differential secretary proteomics analysis of tumor micro- environment in solid tumors. The National Basic Research Program of China (973 program). (China). 2011/01-2014/12.

·           No.09PJD005. The effect of immuno cells in preventing the development of Alzheimer’s diseases in APPswe/PSENldE9 mice. Shanghai Pujiang Talent Program. (China). 2009/10-2011/09

·           No. 30871312. The role of Foxp3 in regulating the microRNAs of Tregs. National Science Foundation of China. (China). 2009/01-2011/12

·           No. 30500280. The function and infiltration of Tregs in Tumor microenvironment mediated by SLC/CCR7 axis. National Science Foundation of China. (China). 2006/01- 2008/12.

Awards and Honors

·           Awarded with Research Scholarship Grant for outstanding Post Doc, Austrian Academic Exchange Service, Austrian (2007-2008)

Paper Highlight

1.   Chen L, Zhou S, Qin J, Hu H, Ma H, Liu B, Wang X,Ma J, Ye S, Zhong C, Zhou G, Liang C*. (2013). Combination of SLC Administration and Tregs Depletion Results in the Maximal Tumor Regression. Molecular Cancer. 12(1):153-164.

2.   Liang CM, Zhong CP, Sun RX, Liu BB, Huang C, Qin J, Zhou S, Shan J, Liu YK, Ye SL. Local expression of secondary lymphoid tissue chemokine delivered by adeno-associated virus within the tumor bed stimulates strong anti-liver tumor immunity. (2007). J Virol. 81(17):9502-11.

Selected Publications

1.   Chen L, Zhou S, Qin J, Hu H, Ma H, Liu B, Wang X,Ma J, Ye S, Zhong C, Zhou G, Liang C*. (2013). Combination of SLC Administration and Tregs Depletion Results in the Maximal Tumor Regression. Molecular Cancer. 12(1):153-164.

2.   Li R, Hu H, Ma H, Chen L, Zhou S, Liu Y, Liang C*. (2013). Tregs infiltration effect antitumor mediated by rAAV-SLC.. Molecular Biology Report. 40(10):5615-23

3.   Zhou S, Shen Z, Wang Y, Ma H, Zhong C, Yang Y, Liang C*. (2013). CCR7 Expression and Intratumoral FOXP3+ Regulatory T Cells are Correlated with Overall Survival and Lymph Node Metastasis in Gastric Cancer. PLoS ONE. 8(9): e74430. doi:10.1371/journal.pone. 0074430,.

4.   Sheng Z, Zhou S, Wang Y, Li R, Qin J, Liang C*, Sun Y. (2010).Higher intratumoral infiltrated Foxp3+ Treg numbers and Foxp3+/CD8+ ratio are associated with adverse prognosis in resectable gastric cancer. J Can Res Clin Oncol. 136:1585–1595

5.   Zhou S, Li RL, Qin J, Zhong CP, Liang CM*. SLC/CCR7 stimulates the proliferation of BMDCs by the pNF-κB p65 pathway. (2010). Anat Rec. 293(1):48-54.

6.   Li S, He H, Cui W, Gu B, Li J, Qi Z, Zhou G, Liang CM^*, Feng XY. (2010) . Detection of Aβ plaques by a novel specific MRI probe precursor CR-BSA-(Gd-DTPA)n in APP/PS1 transgenic mice.Anat Rec. 293(12):2136-43.

7.   Liang CM, Ye SL, Zhong CP, Zheng N, Bian W, Sun RX, Chen J, Li RL, Zhou S, Liu YK. ( 2007). More than chemotaxis: a new anti-tumor DC vaccine modified by rAAV2-SLC. Mol Immunol.44(15):3797-804.

8.   Liang CM, Zhong CP, Sun RX, Liu BB, Huang C, Qin J, Zhou S, Shan J, Liu YK, Ye SL. Local expression of secondary lymphoid tissue chemokine delivered by adeno-associated virus within the tumor bed stimulates strong anti-liver tumor immunity. (2007). J Virol. 81(17):9502-11.