Course Syllabus:
Week 1 Geneticdisease & Gene Mutation
Outline
A. Arrangement of the course
B. Introduction of the tasks &the history of Genetics
C. Medical Genetics(tasks & rules of Medical Genetics)
D.Genetic disease(including classification, Characteristics of genetic disorders )
Week 2 Single gene disorder
Outline
A. Historical Background
B. Patterns of inheritance
C. Genetic mutations & Diseases
D. Prenatal diagnosis
Seminar in groups: (After classes)
Week 3 Polygenic disorder
Outline
A. Historical background
B. Phenotypes in populations
C. Genes in populations
D. Mapping disease genes
E. Complex disorders
Seminar in groups: (After classes)
Week 4 Mitochondrial disease
Outline
A. Characteristics of mtDNA(replication, transcription, translation)
B. Replication, Transcription, Translation of mtDNA
C. Characteristics of Mitochondrial disease
D. Mitochondrial disease
Week 5 Chromosome disorder
Outline
A.The human genome and its chromosomes
B. The origin of chromosome abnormalities
C. Chromosome disorders
After listening to this lecture you should have a better understanding of: 1.The role “karyotype” analysis in the discovery and diagnosis of human chromosome disorders. 2. The molecular and cellular origins of chromosome abnormalities. 3.Several famous chromosome disorders. 4. The role of DNA methylation in the regulation of gene expression and human disease.
Seminar in groups: (After classes)
Week 6 Birth defect
Outline
A. General Introduction of Birth defect
B. Forms of Birth Defects
C.The cause of birth defects
D.Spina Bifida
Week 7 Cancer and Gene
Outline
A .General Introduction of Cancer and Gene
B. Oncogene
C. Tumor Suppressor Genes
D.Multi-stage Carcinogenesis
Week 8 Student presentation
Week 9 Student presentation
