当前位置: 首页  教学团队  李炜 副教授
李炜 副教授

基本

信息

姓 名

李炜

性别

出生年月


最终学历

研究生

职 称

讲师

电 话

51980118

博士

职 务


传 真


所在院系

药学院

E-mail

wei-li@fuan.edu.cn

通信地址(邮编)

上海市浦东新区张衡路826号,邮编:201203

教学

情况

近五年来讲授的主要课程


主要课程:

药物设计学:      本科专业课,4学时/周,历届,约80人。

临床药物化学:    本科专业课,2学时/周,历届,约10人。

高等药物化学选论:研究生专业基础课,3学时/周,历届,约20

药物设计进展:    研究生专业课,3学时/周,历届10人。

实践性教学:

实验合成药物化学I本科专业基础课,6学时/周,历届,约100

实验合成药物化学II本科专业课,6学时/周,历届,约20

本科毕业论文:历届,年均1人。

参编教材:叶德泳,李炜 Chapter 6: Central   Nervous System Drugs 《药物化学》双语教材

(英中双语注解版)p.p. 191-254; 李绍顺主编,北京:科学出版社,20097

教学论文:

1.       李炜,王洁,谢琼,杨翠芬,王洋实验记录随堂检查与讨论制度在实验药物化学课程中的应用;《药学教育》,2013291):46-49.

2.       李炜,叶德泳,仇缀百,鹿文博基于创新型人才培养的药物设计学课程建设与改革;《药学教育》,2011271):25-28.

学术

研究

负责的研究课题:

1.        含阿片κ位码的稠环吗啡类配基的设计、合成与药理研究;上海市自然科学基金 (2008-2010 08ZR1401500)

2.        具有μ/δ双重作用的芳基氮杂七元环类配基的设计、合成与生物活性研究;国家自然科学基金(2010-2012,青年基金项目, 30901857)

近五年SCI论文:

1. Hui-Jiao Sun, Yu-Hua Wang, Cong-Min Yuan, Ling-Hui Kong, Xue-Jun Xu, Yu-Jun Wang, Hai-Hao Wu, Cheng Lin, Yuan-Yuan Qian, Huo-Ming Huang, Li Xiao, Xiao Liu, Qian He, Sheng-Yang Fang, Deng-Qi Xue, Xi-Cheng Yanga, Hao Chen, Yi-Lin Zheng, Lan Zheng, Lin-Qian Yu, Qiong Xie, Wei Fu, Wei Li*, Jing-Gen Liu*, Zhui-Bai Qiu, Li-ming Shao*. 7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg Med Chem, 2018, 26(14), 4254-63.


2. Wei Li#, Jian-Dong Long#, Yuan-Yuan Qian#, Yu Long, Xue-Jun Xu, Yu-Jun Wang, Qing Shen, Zuo-Neng Wang, Xi-Cheng Yang, Li Xiao, Hong-Peng Sun, Yu-Long Xu, Yi-Yi Chen, Qiong Xie, Yong-Hui Wang, Li-Ming Shao, Jing-Gen Liu*, Zhui-Bai Qiu, Wei Fu*. The pharmacological heterogeneity of nepenthone analogs in conferring highly selective and potent kappa-opioid agonistic activities. ACS Chem NeuroSci, 2017, 8 (4), 766–76.


3. Jian Shen#, Xi-cheng Yang#, Ming-cheng Yu, Li Xiao, Xun-jie Zhang, Hui-jiao Sun, Hao Chen, Guan-xin Pan, Yu-rong Yan, Si-chen Wang, Wei Li*, Lu Zhou*, Qiong Xie, Lin-qian Yu, Yong-hui Wang, Li-ming Shao*. Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands. Acta Pharmacol Sin, 2017, 38(1): 146-55. 

4. Yulong Xu, Yi-yi Chen, Wei Li, Qiong Xie, Liming Shao*. Microwave-assisted synthesis of phenanthridines by radical insertion/cyclization of biphenyl isocyanides. J Org Chem, 2016, 81: 8426-35.

5. Wei Li#, Jian Wu#, Lili Xu#, Peng Du, Xuechu Zhen*, Wei Fu*. Functional reversal of (-)-Stepholidine analogues by replacement of benzazepine substructure using the ring-expansion strategy, Chem Biol Drug Des, 2016, 88(4), 599-607.

6. Qing Shen, Yuanyuan Qian, Xiaoqin Huang, Xuejun Xu, Wei Li*, Jinggen Liu*, and Wei Fu*. Discovery of potent and selective agonists of delta opioid receptor by revisiting the “Message-Address” concept. ACS Med Chem Lett, 2016, 7 (4), 391–6.

7. Qing Shen, Yuan-yuan Qian, Xue-jun Xu, Wei Li*, Jing-gen Liu*, Wei Fu*. Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel mu opioid receptor ligands. Acta Pharmacol Sin, 2015, 36: 887-94.

8. Yulong Xu, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao*, A convenient aqueous copper-catalyzed synthesis of quinazolinones. Tetrahedron, 2015, 72(29):4853-8.

9. Anna W. Sromek, Shaohui Zhang, Vamsidhar Akurathi, Alan B. Packard, Wei Li, David Alagille, Thomas J. Morley, Ronald Baldwin, Gilles Tamagnan, John L. Neumeyer*. Convenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3- fluoropropanoxy-11-hydroxy noraporphine. J Labelled Compd Radiopharm, 2014, 57(14):725-9.

10. Brian A. Provencher, Anna W. Sromek, Wei Li, Shayla Russell, Elena Chartoff, Brian I. Knapp, Jean M. Bidlack, John L. Neumeyer*. Synthesis and pharmacological evaluation of aminothiazolo morphinans at the mu and kappa opioid receptors. J Med Chem, 2013, 56, 8872-8.