学术 研究 | 承担学术课题 1. 具有μ/δ双重作用的芳基氮杂七元环类配基的设计、合成与生物活性研究;国家自然科学基金(2010-2012,青年基金项目,课题负责人,项目批准号:30901857) 2. 含阿片κ新“位码”的稠环吗啡类配基的设计、合成与药理研究;上海市自然科学基金 (2008-2010,课题负责人,编号08ZR1401500) 学术论文: 1. QI Hong, LI Wei (Co-first author), QIU Yu*, CUI Yong-yao, MAO Jian, GAO Xiao-lin, Zeng Yi-bin, YANG Jie, TANG Yun, WANG Xing-hai, SHENG Wei, XIE Qiong, LIU Jing-gen, QIU Zhui-bai, CHEN Hong-zhuan. Synthesis and evaluation of κ-opioid receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α, 14α-endo-etheno-tetrahydrothebaine with substituted o-, m- and p- amino group. Medicinal Chemistry Research, 2011, 20(8): 1364-1370. 2. LI Wei, TAO Yi-min, TANG Yun, XU Xue-jun, Chen Jie, FU Wei, WANG Xingh-hai, CHAO Bo, SHENG Wei, XIE Qiong, QIU Zhui-bai*, LIU Jing-gen*. Highly selective and potent μ opioid ligands by unexpected substituent on morphine skeleton. Bioorg Med Chem Lett 2010, 20(1), 418-421. 3. LI Wei, WANG Xing-hai, TANG Yun*, XIE Qiong, LAU Choiwan, QIU Zhui-bai*. Conformational re-analysis of (+)-meptazinol: an opioid with mixed analgesic pharmacophores. Acta Pharmacol Sin 2006, 27(9): 1247-52. 4. LI Wei, TANG Yun*, XIE Qiong, SHENG Wei, QIU Zhui-bai*. 3D-QSAR studies of orvinol analogs as κ opioid agonists. J Mol Model 2006, 12(6): 877-84. 5. LI Wei, TANG Yun*, ZHENG You-li, QIU Zhui-bai*. Molecular modeling and 3D-QSAR studies on indolomorphinan derivatives as kappa opioid antagonists. Bioorg Med Chem 2006, 14(3): 601-10. 6. LI Wei, HAO Jing-lai, TANG Yun, CHEN Yan, QIU Zhui-bai*. Structural comparisons of meptazinol with opioid analgesics. Acta Pharmacol Sin 2005, 26(3): 334-8. |