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学术研究 | 近五年来承担的学术研究课题（含课题名称、来源、年限、本人所起作用）
（1）脂筏蛋白flotillin-1 调节细胞膜延迟整流外向钾通道的机制，国家自然科学基金面上项目（No30870569），2009-2012, 项目主持人
（2）花生四烯酸双向调控电压门控钠通道的机制，国家自然科学基金面上项目（No30670472），2007-2009，项目主持人
（3）离子芬钠酸双向调节瞬时外向钾通道的分子机制，教育部博士点基金 （20060246018），2006-2008，项目主持人
（4）磷酸化信号修饰细胞膜离子通道对神经元的保护作用研究，上海市科学技术发展基金重点项目（No04JC14020），2004-2006，项目主持人
（5）TGF-B诱导成纤维细胞IA离子通道表达的信号通路及其在细胞表型转化中的作用，国家自然科学基金面上项目（No30370346），2004-2006
在国内外公开发行刊物上发表的学术论文（含题目、刊物名称、署名次序次序与时间） 1. Man Zhang, Xiao-Wei Fei, Yan-Lin He, Guang Yang, and Yan-Ai Mei. Bradykinin inhibits the transient outward K+ current in mouse Schwann cells via the cAMP/PKA pathway. Am J Physiol Cell Physiol. 2009,296:C1364-72 2. Hua Gu, Yan-Jia Fang, Yan-Lin He, Ji Sun, Jian Zhu, Yan-Ai Mei . Modulation of muscle rNav1.4 Na+ channel isoform by arachidonic acid and its non-metabolized analog. J Cell Physiol. 2009 , 219:173-82. 3. Hu CL, Zeng XM, Zhou MH, Shi YT, Cao H, Mei YA. Kv1.1 is associated with neuronal apoptosis and modulated by protein kinase C in the rat cerebellar granule cell. J Neurochem 2008; 106:1125–1137. 4. Zheng Liu, Xiao-Wei Fei, Yan-Jia Fang, Wen-Jie Shi, Yu-Qiu Zhang, Yan-Ai Mei. PLC-dependent intracellular Ca2+ release was associated with C6-ceramide-induced inhibition of Na+ current in rat granule cells. J Neurochem 2008; 106:2463–2475. 5. Zhang M, Shi WJ, Fei XW, Liu YR, Zeng XM, Mei YA. Mefenamic acid bi-directionally modulates the transient outward K+ current in rat cerebellar granule cells. Toxicology and Applied Pharmacology 2008 226(3):225-35. 、 6. Ya-Rong Liu, Wen-Lei Ye, Xi-Min Zeng, Wen-Hua Ren, Yu-Qiu Zhang, and Yan-Ai Mei. K+ channels and the cAMP–PKA pathway modulate TGF-b1-induced migration of rat vascular myofibroblasts. J. Cell. Physiol. 2008, 216: 835–843. 7. Zheng-Ge Zhao, Man Zhang, Xi-Min Zeng, Lin-Yun Liu, Zhi-Hong Zhang, Yan-Ai Mei. Flufenamic acid bi-directionally modulated the transient outward K+ current in rat cerebellar granule cells The Journal of Pharmacology and Experimental Therapeutics 2007, 322:195-204 8. Zheng Liu, Jian-Guang Xu, Hua Zhang, Yan-Jia Fang, Yan-Ai Mei. C6-ceramide inhibited Na+ currents by intracellular Ca2+ release in rat myoblasts Journal of Cellular Physiology 2007 25；213: 151–160, 2007 9. Lin-Yun Liu, Gloria E. Hoffman, Xiao-Wei Fei, Zhi-Hong Zhang, Yan-Ai Mei. Delayed rectifier outward K+ current mediates the migration of rat cerebellar granule cells stimulated by melatonin。 Journal of Neurochemistry 2007, 102, 333–344. 10. Song Jiao, Zheng Liu, Yu Ding, Chang-Long Hu, Zhi-Hong Zhang, Yan-Ai Mei. cAMP/PKA signalling pathway protects against neuronal apoptosis and is associated with modulation of Kv2.1 in cerebellar granule cells. Journal of Neurochemistry 2007, 100, 979–991. 11. Zhaomin Li, Yanai Mei, Xifu Liu, Mingdong Zhou. Cellular Signalling Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners. 2007, 19: 466–471. 12. Chang-Long Hu, Zheng Liu, Xi-Min Zeng, Zi-Qiang Liu, Xian-Hua Cheng, Zhi-Hong Zhang, Yan-Ai Mei. 4-aminopyridine, a Kv channel antagonist, prevents apoptosis of rat cerebellar granule neurons. Neuropharmacology 2006，51：737-746. 13. Xiao-Wei Fei, Lin-Yun Liu, Jian-Guang Xu, Zhi-Hong Zhang，Yan-Ai Mei. The non-steroidal anti-inflammatory drug, diclofenac, inhibits Na+ current in rat myoblasts. Biochem Biophys Res Commun. 2006, 346(4):1275-83. 14. Xin Wang, Jie Bao, Xi-Min Zeng, Zheng Liu, and Yan-Ai Mei. Elevation of intracellular Ca2+ modulates A-currents in rat cerebellar granule neurons. Journal of Neuroscience Research 2005 (4): 530-540 AUG 15. 15. Bo-Xun Lu, Lin-Yun Liu, Zhao-Ming Li, Zhi-Hong Zhang, Yan-Ai Mei. Inhibition of Na+ channel currents in rat myoblasts by 4-aminopyridine. Toxicology and Applied Pharmacology. 2005, 207(3):275-82. 16. Lin-Yun Liu, Xiao-Wei Fei, Zhao-Min Li, Yan-Ai Mei. The nonsteroidal anti-inflammatory drug, diclofenac, activates the transient outward K+ current in rat cereballer granule cells. Neuropharmacology 2005 ,48: 918-926. 17. Hu Chang-Long, Gao Zhen-Yu, Liu Zheng, Zhang Zhi-Hong, Mei Yan-Ai. 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via inhibition of A-type transient outward K+ currents. J. Pineal Res. 2005, 38:53-61. 18. Liao L, Zeng XM, Gao PJ, Zhu DL, Mei YA .PKC pathway associated with the expression of an A-type K+ channel induced by TGF-beta1 in rat vascular myofibroblasts. Biochem Biophys Res Commun. 2005 Oct 28;336(3):854-9. 19. Yan-ai Mei, D. Vaudry et al, PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway. Evidence for the involvement of Ik in the anti-apoptosis action of PACAP. Eur. J. Neuronsci. 2004 14:225-230. 20. MiOu Zhou, Zheng Liu, ChangLong Hu, ZhiHong Zhang and Yan-Ai Mei. Developmental Regulation of a Na+-activated Fast Outward K+ Current in Rat Myoblasts. Cell Physiol Biochem 2004;14 ：225-230. 21. Lin-Yun Liu , Chang-Long Hu, Lai-ji Ma, Zhi-hong Zhang, and Yan-Ai Mei. ET-1 inhibits B-16 murine melanoma cell migration by decreasing K+ currents. Cell Motility Cytoskel . 2004: 58:127–136. 22. Song Jiao, Ming-Ming Wu, Chang-Long Hu, Zhi-Hong Zhang and Yan-Ai Mei. Melatonin receptor agonist 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via K+ currents inhibition. J. Pineal Res. 2004; 36:109-116. 23. Lai-Ji Ma , Lin-Yun Liu, Song Jiao, Shao-Ming Wei, Yan-Ai Mei Ca2+- inactivated K+ current modulated by endothelin-I in B-16 murine melanoma cells. Pigment Cell Res. 2003,16:463-469. 24. ZHOU Mi-ou, JIAO Song, LIU Zheng, ZHANG Zhi-hong, Mei Yan-ai. Luzindole, a melatonin receptor antagonist, inhibits the transient outward K+ current in rat cerebellar granule cells. Brain Res.2003,970: 169-177. 25. Wu M, Gao P, Jiao S, Zhu D, Zhang Z, Mei Y.A. TGF-1 induceds the expression of inactivating K+(IA) channels in rat vascular myofiblast. Biochem Biophys Res Commun 2003 30:17-23. 2.836 26.Hua Wei, Yan Ai Mei, Jia Ting Sun, Han Ging Zhou, Zhi Fong Zhang. Regulation of sewlling-activated chloride channels in embryonic chick heart cells. Cell Res. 2003, 1: 21-28. 27. Wei DS, Mei YA, Bagal A, Kao JP, Thompson SM, Tang CM. Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons. Science. 2001 Sep 21;293(5538):2272-5. 28. Mei YA, Lee PP, Wei H, Zhang ZH, Pang SF. Melatonin and its analogs potentiate the nifedipine-sensitive high-voltage-activated calcium current in the chick embryonic heart cells. J Pineal Res. 2001 Jan; 30(1):13-21. 29. Huan CL, Zhou MO, Wu MM, Zhang ZH, Mei YA. Melatonin receptor Activate the rectify inward K+ current by a MT2 melatonin receptor in cerebellar granule cells. Brain Res, 2001,917:182-190. 30. Wei H, Mei YA, Wu MM, Sun JT, Zhou HQ, Zhang ZH. Swelling-activated chloride currents in embryonic chick heart cells. Acta Pharmacol Sinica. 2000 Nov; 21(11):986-90. 31. Mei YA, Wu MM, Huan CL, Sun JT, Zhou HQ, Zhang ZH. 4-aminopyridine, a specific blocker of K(+) channels, inhibited inward Na(+) current in rat cerebellar granule cells. Brain Res. 2000 Aug 4;873 (1):46-53.
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