基础医学研究入门

授课教师:支秀玲副教授

发布者:王松梅发布时间:2017-03-29浏览次数:118

支秀玲,1975年3月出生,博士,复旦大学基础医学院副教授,硕士生导师,中国病理生理学会肿瘤专业委员会青年委员

近年来主要从事肿瘤转移及炎症机制的研究。迄今在HepatologyBiochim Biophys Acta等杂志共发表SCI科研论文20篇,其中以第一作者或通讯作者发表SCI论文8篇。作为课题负责人承担5项科研项目,在研2项: 1项国家自然科学基金面上项目(项目编号:81572713,直接经费62万),1项上海市自然科学基金面上项目(项目编号:14ZR1401500,资助金额10万);结题3项:1项国家自然科学基金青年基金项目(项目编号:81001170,资助金额22万),1项复旦大学上海医学院青年骨干基金,1项复旦大学新教师科研启动基金。承担分子生物学及相关课程的教学工作并积极参与教学改革,承担1项复旦大学基础医学院教学改革研究项目(在研)。

主要论著

1.Qiu Y, Sui X, Zhan Y, Xu C, Li X, Ning Y, Zhi X*, Yin L.Steroidogenic acute regulatory protein (StAR) overexpression attenuates HFD-induced hepatic steatosis and insulin resistance.Biochim Biophys Acta. 2017 Jan 30;1863(4):978-990.*co-corresponding

2.Zhi X, Lin L, Yang S, Bhuvaneshwar K, Wang H, Gusev Y, Lee MH, Kallakury B, Shivapurkar N, Cahn K, Tian X, Marshall JL, Byers SW, He AR.βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin. Hepatology. 2015 Feb;61(2):598-612.

3.Li M, Yang X, Zhang Y, Chen L, Lu H, Li X, Yin L, Zhi X*.Activation of protease‑activated receptor‑2 is associated with increased expression of inflammatory factors in the adipose tissues of obese mice. Mol Med Rep. 2015 Aug12: 6227-6234.*co- corresponding

4.Zhi X, Xu C, Zhang H, Tian D, Li X, Ning Y, Yin L.Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice. PLoS One. 2013;8(4):e60960.

5.Zhi X, Wang Y, Yu J, Yu J, Zhang L, Yin L, Zhou P.Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer. IUBMB Life. 2012 Nov;64(11):911-20.

6.Zhi X, Wang Y, Zhou X, Yu J, Jian R, Tang S, Yin L, Zhou P.RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells. Cancer Sci. 2010 Dec;101(12):2561-9.

7.Zhi X, Chen S, Zhou P, Shao Z, Wang L, Ou Z, Yin L.RNA interference of ecto-5'-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion. Clin Exp Metastasis. 2007;24(6):439-48

8.Zhou P, Zhi X*, Zhou T, Chen S, Li X, Wang L, Yin L, Shao Z, Ou Z.Overexpression of Ecto-5'-nucleotidase (CD73) promotes T-47D human breast cancer cells invasion and adhesion to extracellular matrix.Cancer Biol Ther. 2007 Mar;6(3):426-31.  (*co-first author

9.Yu J, Liao X, Li L, Lv L, Zhi X, Yu J, Zhou P A preliminary study of the role of extracellular -5'- nucleotidase in breast cancer stem cells and epithelial-mesenchymal transition. In Vitro Cell Dev Biol Anim. 2017 Feb;53(2):132-140.

10.Wang Z, Yang X, Chen L, Zhi X, Lu H, Ning Y, Yeong J, Chen S, Yin L, Wang X, Li X.Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury.Arch Toxicol. 2017 Jan;91(1):271-287. doi: 10.1007/s00204-016-1693-z.

11.Tian X, Shivapurkar N, Wu Z, Hwang JJ, Pishvaian MJ, Weiner LM, Ley L, Zhou D, Zhi X, Wellstein A, Marshall JL, He AR.Circulating microRNA profile predicts disease progression in patients receiving second-line treatment of lapatinib and capecitabine for metastatic pancreatic cancer.Oncol Lett. 2016 Mar;11(3):1645-1650.

12.Yang X, Xu Y, Guo F, Ning Y, Zhi X, Yin L, Li X. Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo. PLoS One. 2013 Apr 11;8(4):e60853.

13.Wang L, Tang S, Wang Y, Xu S, Yu J, Zhi X, Ou Z, Yang J, Zhou P, Shao Z.Ecto-5'-nucleotidase (CD73) promotes tumor angiogenesis.Clin Exp Metastasis. 2013 Jun;30(5):671-80.

14.Tian D, Qiu Y, Zhan Y, Li X, Zhi X, Wang X, Yin L, Ning Y.Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.Cardiovasc Diabetol. 2012 Nov 21;11:144.

15.Xu Y, Liu X, Guo F, Ning Y, Zhi X, Wang X, Chen S, Yin L, Li X.Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.Cancer Sci. 2012 Jun;103(6):1000-9.

16.Jiang T, Zhi XL, Zhang YH, Pan LF, Zhou P.Inhibitory effect of curcumin on the Al(III)-induced Aβ₄₂ aggregation and neurotoxicity in vitro.Biochim Biophys Acta. 2012 Aug;1822(8):1207-15.

17.Zhou X, Zhi X, Zhou P, Chen S, Zhao F, Shao Z, Ou Z, Yin L. Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo. Oncol Rep. 2007 Jun;17(6):1341-6.

18.Li X, Zhou T, Zhi X, Zhao F, Yin L, Zhou P. Effect of hypoxia/reoxygenation on CD73(ecto-5'-nucleotidase) in mouse microvessel endothelial cell lines. Microvascular Research,2006(72):48-53.

19.Wang L, Zhou X, Zhou T, Ma D, Chen S, Zhi X, Yin L, Shao Z, Ou Z, Zhou P. Ecto-5'-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells. J Cancer Res Clin Oncol. 2008 ,134(3):365-372.

20.Sun Y, Chen L, Yu J, Zhi X, Tang S, Zhou P, Wang C. Folate-bearing doxorubicin-loaded magnetic poly(N-isopropylacrylamide) microsphere as a new strategy for cancer therapy. Anti-Cancer Drugs 2009,20:607-615

21.Jiang Y, Zhao F, Li X, Ning Y, Zhi X, Qian R, Yin L. Effects of RNA interference-induced tryptase down-regulation in P815 cells on IL-6 and TNF-α release of endothelial cells. Zhejiang Univ Sci B. 2008 ;9(8):656 :656-661


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